HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1689207Generated: October 30, 2026
Triethylamine → 4-(3-(4-(2-Methylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propoxy)benzaldehyde
https://huagongshe.com/reaction/1689207
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(3-Bromopropoxy)benzaldehyde | HCID 13715789 | — |
| Reactant | (2-Methylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate | HCID 66964121 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(3-(4-(2-Methylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propoxy)benzaldehyde | HCID 57989105 | — |
Reaction Steps
A mixture of (2-methylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate (example 4, step h) (0.244 g), 4-(3-bromopropoxy)benzaldehyde (example 8, step a) (0.15 g) and triethylamine (0.344 mL) in MeCN (2 mL) was heated at 60° C. After 16 h, the reaction mixture was evaporated in vacuo. Purification was by silica gel chromatography eluting with ethyl acetate:triethylamine, 10:1 to give the subtitled compound as an oil. Yield 0.24 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08148373B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-df1b6b6ffbc54f8284bff6daf0e79738 |
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| Source note | uspto-grants-2012_04 |
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