反应详情

To a solution of (2-methylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate (example 4, step h) (0.791 g) and triethylamine (0.697 mL) in acetonitrile (10 mL) was added 2-(4-(bromomethyl)phenyl)ethanol (example 16, step a) and the resulting mixture stirred overnight. The solvent was evaporated in vacuo. The residue was partitioned between ethyl acetate (25 mL) and saturated sodium bicarbonate solution (25 mL). The aqueous phase was separated and extracted with ethyl acetate (2×25 mL). The combined organic solutions were washed with brine (25 mL), dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound as a yellow oil. Yield 0.76 g.

1. customThe solvent was evaporated in vacuo
2. customThe residue was partitioned between ethyl acetate (25 mL) and saturated sodium bicarbonate solution (25 mL)
3. customThe aqueous phase was separated
4. extractionextracted with ethyl acetate (2×25 mL)
5. washThe combined organic solutions were washed with brine (25 mL)
6. dry with materialdried over sodium sulphate
7. filtrationfiltered
8. customevaporated in vacuo