Sodium Hydroxide → HCID 23530588, compound

Temperature

75 °C

A solution of 1-(4-isopropylthiophen-2-yl)ethanone (example 74, step a) (1 g) in 1,4-dioxane (10 mL) was cautiously added to a solution of sodium hydroxide (1.19 g) in aqueous sodium hypochlorite (8%, 50 mL) at 60° C. The resulting mixture was heated to 75° C. and stirred for 1 h. The reaction was allowed to cool and the aqueous phase washed with DCM (50 mL). The aqueous phase was treated with aqueous sodium bisulphite solution (10%, 20 mL) and carefully acidified with concentrated hydrochloric acid. The resulting mixture was extracted with DCM (3×50 mL). The combined organic solutions were dried over sodium sulphate, filtered and evaporated to give a yellow oil. Purification was by preparative HPLC (Sunfire™, Gradient: 5-95% acetonitrile in 0.2% aqueous TFA). The fractions containing product were combined, evaporated and dried under high vacuum to give the subtitled compound as a white solid. Yield 0.5 g.

1. temperatureto cool
2. washthe aqueous phase washed with DCM (50 mL)
3. additionThe aqueous phase was treated with aqueous sodium bisulphite solution (10%, 20 mL)
4. extractionThe resulting mixture was extracted with DCM (3×50 mL)
5. dry with materialThe combined organic solutions were dried over sodium sulphate
6. filtrationfiltered
7. customevaporated
8. customto give a yellow oil
9. customPurification
10. additionThe fractions containing product
11. customevaporated
12. customdried under high vacuum

ORD record

ord-1ac2306da87e478682bfadb97c76e7a0

Source dataset

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08148373B2