Dimethyl Sulfate → HCID 178463843, compound

HRID 1689558Notes

Reaction equation

HRID 1689558 reaction equation
[CH2:1]([N:3]([CH2:36][CH3:37])[C:4]1[CH:9]=[CH:8][C:7](/[N:10]=[N:11]/[C:12]2[S:13][C:14]([CH:24]=[C:25]3[C:33](=[O:34])[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:26]3=[O:35])=[C:15]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]3)[N:16]=2)=[CH:6][CH:5]=1)[CH3:2].[CH3:38][O:39][S:40]([O:43]C)(=[O:42])=[O:41]>C(#N)C>[CH3:38][O:39][S:40]([O-:43])(=[O:42])=[O:41].[CH2:36]([N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][C:7](/[N:10]=[N:11]/[C:12]2[S:13][C:14]([CH:24]=[C:25]3[C:33](=[O:34])[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[C:26]3=[O:35])=[C:15]([N:17]3[CH2:22][CH2:21][N+:20]([CH3:38])([CH3:23])[CH2:19][CH2:18]3)[N:16]=2)=[CH:6][CH:5]=1)[CH3:37]

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 178463842HCID 178463842, compound

Product 1

HCID 178463843HCID 178463843, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.93 g (1.80 mmol) 2-{[2-{(E)-[4-(diethylamino)phenyl]diazenyl}-4-(4-methyl-1-piperazinyl)-1,3-thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione was dissolved in 20 ml acetonitrile. After addition of 0.5 g (3.70 mmol) dimethylsulfate, the mixture was heated under reflux for 24 hours. After cooling to room temperature the formed precipitate was filtered off and dried in vacuum at 40° C. to obtain a dark green solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. filtrationwas filtered off
  4. customdried in vacuum at 40° C.
  5. customto obtain a dark green solid

Sources & evidence

ORD record
ord-d7f81e9a42444a8fb80ec7cbe9ede5d5
Source dataset
uspto-grants-2012_04
Patent number
US08152861B2

Reaction notes

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