Chlorosulfonic acid → HCID 66906927, compound

HRID 1689578Notes

Reaction equation

[N+]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH:13][S:14]([C:17]2[C:18]3[C:19]4[C:23](=[CH:24][CH:25]=2)[NH:22][C:21](=[O:26])[C:20]=4[CH:27]=[CH:28][CH:29]=3)(=[O:16])=[O:15])(F)[CH3:11])=[CH:6][CH:5]=1)([O-])=O.[NH:30]1C2C3C(=CC=CC=3[C:31]1=O)C=CC=2.ClS(O)(=O)=[O:45]>O>[C:31]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH:13][S:14]([C:17]2[C:18]3[C:19]4[C:23](=[CH:24][CH:25]=2)[NH:22][C:21](=[O:26])[C:20]=4[CH:27]=[CH:28][CH:29]=3)(=[O:16])=[O:15])([OH:45])[CH3:11])=[CH:6][CH:5]=1)#[N:30]

Participants

Conditions

Temperature: 60 °C

Procedure

MATERIALS AND METHODS: All chemicals and reagents were used as received from the supplier. TLC's were run on EMD Silica Gel 60 F254 coated plates. Melting points were determined using a Fisher-Johns melting point apparatus and are uncorrected. 1H-NMR spectra were run on a Bruker Advance WB 300 MHz instrument, using TMS as an internal standard. 1-Hydroxy-1-(4-cyanophenyl)bromoethane (1). Sodium borohydride reduction of 4-cyano-α-bromoacetophenone produced hydroxy compound (1). 6-Chlorosulfonylbenz[cd]indol-2(1H)-one (2). Benz[cd]indol-2(1H)-one (2.523 g; 14.9 mmoles) was added slowly to 5.1 ml of chlorosulfonic acid while keeping the temperature below 15° C. The reaction mixture was heated to 60° C. and held there until no more HCL gas evolved. Then, the reaction mixture was poured into 125 ml of cold water. The resulting solid suspension was extracted twice with ethyl acetate. The combined ethyl acetate extracts were washed with water, saturated sodium bicarbonate, saturated brine, then dried with sodium sulfate. The solvent was removed and the residue was recrystallized from chloroform/ethyl acetate. The yield of the sulfonamide compound was 1.620 g (41%). A Beilstein test confirmed the presence of the chlorine atom. Melting point was 194-197° C. (dec) 1H-NMR (d6DMSO) δ 6.86 (d, 1H, Ar), 7.79 (m, 2H, Ar), 7.98 (d, 1H, Ar), 8.72 (d, 1H, Ar), 10.83 (s, 1H, NH). 6-{N-[1-(4-cyanophenyl)-1-hydroxyethyl]sulfamoyl}benz[cd]indol-2-(1H)-one (3). 1-Hydroxy-1-(4-cyanophenyl)bromoethane (1), 4-chlorosulfonylbenz [cd]indol-2(1H)-one (4), and triethylamine were dissolved in anhydrous dimethylformamide with stirring. The reaction was heated at 100° C. for 20 hours. The solvent was removed under reduced pressure. The residue was dissolved in ethyl acetate washed with 0.5 N HCl, water, followed by saturated brine. The ethyl acetate layer was dried with sodium sulfate, the solvent was removed and the residue recrystallized to give compound (3). 6-{N-[1-(4-carboxyphenyl)-1-hydroxyethyl]sulfamoyl}benz[cd]indol-2(1H)-one (4). Hydrolysis of 6-{N-[1-(4-cyanophenyl)-1-hydroxyethyl]sulfamoyl}benz[cd]indol-2-(1H)-one (3) gave the carboxylic derivative (4).

Workup

customthe temperature below 15° C
extractionThe resulting solid suspension was extracted twice with ethyl acetate
washThe combined ethyl acetate extracts were washed with water, saturated sodium bicarbonate, saturated brine
dry with materialdried with sodium sulfate
customThe solvent was removed
customthe residue was recrystallized from chloroform/ethyl acetate
dissolution1-Hydroxy-1-(4-cyanophenyl)bromoethane (1), 4-chlorosulfonylbenz [cd]indol-2(1H)-one (4), and triethylamine were dissolved in anhydrous dimethylformamide
temperatureThe reaction was heated at 100° C. for 20 hours
customThe solvent was removed under reduced pressure
dissolutionThe residue was dissolved in ethyl acetate
washwashed with 0.5 N HCl, water
dry with materialThe ethyl acetate layer was dried with sodium sulfate
customthe solvent was removed
customthe residue recrystallized

Sources & evidence

ORD record: ord-61a0628145e44ebdb22e9faa71ae4256
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153410B2

Reaction notes

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