Pentafluoropropionic acid → Propanoic acid, 2,2,3,3,3-pentafluoro-, potassium salt (1:1)

HRID 1689722Notes

Reaction equation

HRID 1689722 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].CC([O-])(C)C.[K+:16]>CCOCC>[F:7][C:3]([F:8])([C:2]([F:10])([F:9])[F:1])[C:4]([O-:6])=[O:5].[K+:16]

Participants

4

Reactant 2

HCID 62356Pentafluoropropionic acidHCID 23665647Potassium tert-butoxide

Product 1

HCID 23667659Propanoic acid, 2,2,3,3,3-pentafluoro-, potassium salt (1:1)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Pentafluoropropionic acid (20.5 g, 183 mmol) was slowly added to a solution of KOtBu (29.9 g, 183 mmol) in ether (400 mL) at 0° C. After 30 minutes the ice bath was removed. After stirring at room temperature for 4 hours the suspension was filtered and the cake was washed with ether (200 mL). The fine white solid was placed under vacuum for 16 hours prior to use.

Workup

  1. customAfter 30 minutes the ice bath was removed
  2. filtrationwas filtered
  3. washthe cake was washed with ether (200 mL)
  4. waitThe fine white solid was placed under vacuum for 16 hours

Sources & evidence

ORD record
ord-64a2fad456694822b071bcbc1df8061d
Source dataset
uspto-grants-2012_04
Patent number
US08153622B2

Reaction notes

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