HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 4-Bromomethyl-3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (3-(2,6-Dichlorophenyl)-5-isopropylisoxazol-4-yl)methanol | HCID 10850745 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Bromomethyl-3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazole | HCID 66906440 | — |
Reaction Steps
To a solution of [3-(2,6-dichloro-phenyl)-5-isopropyl-isoxazol-4-yl]-methanol (1.14 g, 4 mmol) in THF (20 mL) is added PBr3 (0.76 mL, 8 mmol). The reaction mixture is stirred at reflux for 30 minutes. The reaction mixture is diluted with EtOAc and washed with 0.2 N HCl. The organic layer is separated, dried (MgSO4), filtered, and concentrated under reduced pressure to give the title compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153624B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-edade6575e5146b2a074f20c85ea4893 |
| Source note | uspto-grants-2012_04 |