反应详情

温度

65 °C

Acetyl chloride (29.43 g, 374 mmol) is added slowly at room temperature to a solution of 6-bromo-indole-3-carboxylic acid (45 g, 187.46 mmol) in 500 mL of methanol and the resulting solution is stirred at 65° C. overnight. The reaction is cooled to room temperature. A white precipitates appears when cooling. After stirring 2 h at room temperature, the solid is filtered off and dried under vacuum. 34.4 g (72%) of the title compound is obtained as a light brown solid. MS (m/e): 254 (M+1)

1. temperatureThe reaction is cooled to room temperature
2. customA white precipitates
3. temperaturecooling
4. stirringAfter stirring 2 h at room temperature
5. filtrationthe solid is filtered off
6. customdried under vacuum