HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 46867019, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester | HCID 57476926 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 46867019 | HCID 46867019 | 89.1% |
Reaction Steps
To a solution of N—BOC-piperazine (300 mg) in MeCN (5 mL) was added potassium carbonate (289 mg) followed by methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester (369 mg). The reaction mixture was heated to reflux for 24 h. After cooling the reaction mixture was diluted with water, extracted into ethyl acetate, dried (MgSO4) and the solvent was removed in vacuo to yield 4-(5-methyl-isoxazol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester (404 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153629B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-bab7f3ee5a124b4aaa179b97b3e2225f |
| Source note | uspto-grants-2012_04 |