HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde | HCID 45789985 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol | HCID 46180605 | 94% |
Reaction Steps
To (66) (1.5 g) in ethanol (30 mL) was added sodium borohydride (1 g). After 4 h the reaction mixture was quenched with brine and the resulting solid was collected by filtration, and air dried to furnish 168 (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-methanol (1.42 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153629B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b42d89d39deb4d6194e0acafee80df86 |
| Source note | uspto-grants-2012_04 |