Trifluoroacetic acid → (R)-1-chloro-4-(2-methylpiperazin-1-yl)phthalazine

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Reaction Steps

(R)-tert-butyl 4-(4-chlorophthalazin-1-yl)-3-methylpiperazine-1-carboxylate (1.20 g, 3.31 mmol) was dissolved in dry dichloromethane (40 mL). Trifluoroacetic acid (8 mL) was added dropwise and allowed to stir at RT for 2 hours. The reaction was added to saturated NaHCO3 (200 mL) and the aqueous phase was extracted with 3×100 mL of dichloromethane. The combined organics were dried (MgSO4) and evaporated to give a pale yellow solid. MS (M+H)+=263.1.

Provenance & Evidence