Potassium Carbonate → HCID 57581476, compound

Participants

Reaction Steps

(2R,5R)-2,5-dimethylpiperazine dihydrobromide (2.08 g, 7.54 mmol), 1,4-dichlorophthalazine (0.500 g, 2.52 mmol), potassium carbonate (2.08 g, 15.0 mmol), and N-methylpyrrolidinone (7 mL) were heated at 120° C. for 6 hours. The reaction was taken up in ethyl acetate (75 mL) washed with aqueous K2CO3 (10%), water, and then saturated sodium chloride. The organics were dried (MgSO4) and evaporated to give a yellow oil. Chromatography over silica gel with a gradient of hexanes/0-40% ethyl acetate gave a yellow oil. MS (M+H)+=277.2.

Provenance & Evidence