HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dichlorophthalazine → HCID 57581523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dichlorophthalazine | HCID 78490 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(1,1-Dimethylethyl) 2-methyl 1,2-piperazinedicarboxylate | HCID 2756818 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | HCID 57581523 | HCID 57581523 | — |
Reaction Steps
1,4-dichlorophthalazine (741 mg, 3.72 mmol), 1-tert-butyl 2-methyl piperazine-1,2-dicarboxylate (1.00 g, 4.09 mmol), N,N-diisopropylethylamine (0.972 mL), and 4-methyl-2-pentanone (6 mL) were heated at 120° for 16 hours. The solvent was removed and the residue purified by chromatography over silica using a gradient of hexanes/0-70% ethyl acetate. The compound was obtained as a white solid. MS (M+H)+=407.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153633B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-cf961439cec34b24b3040c90009a5e5a |
| Source note | uspto-grants-2012_04 |