Trifluoroacetic acid → HCID 57581498, compound

Participants

Reaction Steps

1-tert-butyl 2-methyl 4-(4-chlorophthalazin-1-yl)piperazine-1,2-dicarboxylate (754 mg, 1.85 mmol) was partially dissolved in dichloromethane (20 mL). Trifluoroacetic acid (3.50 mL) was added and the reaction stirred at rt for 4 hours. Saturated sodium bicarbonate (50 mL) was added and stirred for 15 minutes. The layers were separated and the aqueous phase was extracted two more times with dichloromethane. The combined extracts were dried (MgSO4) and evaporated to give a foamy yellow solid. MS (M+H)+=307.1.

Provenance & Evidence