Benzoyl chloride → HCID 57581555, compound

Participants

Reaction Steps

Methyl 4-(4-chlorophthalazin-1-yl)piperazine-2-carboxylate (563 mg, 1.84 mmol) was dissolved in DMF (6 mL) and N,N-diisopropylethylamine (1 mL). Benzoyl chloride (0.23 mL, 2.02 mmol) was added and the mixture stirred at rt for 16 hours. The reaction was taken up in ethyl acetate (80 mL), washed with aqueous K2CO3 (10%), water, and then saturated sodium chloride. The organics were dried (MgSO4) and evaporated to give a yellow oil. Chromatography over silica gel with a gradient of hexanes/0-75% ethyl acetate gave an off-white foam. MS (M+H)+=381.8.

Provenance & Evidence