Benzoyl chloride → HCID 57581494, compound

Participants

Reaction Steps

1-chloro-4-((2S,5S)-2,5-dimethylpiperazin-1-yl)phthalazine (496 mg, 1.79 mmol) was dissolved in DMF (5 mL) and N,N-diisopropylethylamine (0.5 mL). Benzoyl chloride (0.23 mL, 2.02 mmol) was added and the mixture stirred at rt for 16 hours. The reaction was taken up in ethyl acetate (80 mL) and washed with aqueous K2CO3 (10%), water, and saturated sodium chloride. The organics were dried (MgSO4) and evaporated to give a yellow oil. Chromatography over silica gel with a gradient of hexanes/0-70% ethyl acetate gave off-white foam. MS (M+H)+=381.0.

Provenance & Evidence