Benzenesulfonyl chloride → HCID 57581525, compound

Participants

Reaction Steps

Compound 67 was prepared as described in general Method F. (S)-1-(3-methylpiperazin-1-yl)-4-phenylphthalazine (JK-8) (150 mg, 0.493 mmol) was dissolved in DMF (3 mL) and N,N-diisopropylethylamine (0.400 mL). Benzenesulfonyl chloride (104 mg, 0.591 mmol) was added and the reaction stirred at rt for 18 hours. The reaction was taken up in ethyl acetate (75 mL) and washed with aqueous K2CO3 (10%), water, and saturated sodium chloride. The organics were dried (MgSO4) and evaporated to give a brown oil. Chromatography over silica gel with a gradient of hexanes/0-70% ethyl acetate gave 67 as an off-white solid. MS (M+H)+=445.2

Provenance & Evidence