反应详情

温度

180 °C

2-(4-Chloro-quinazolin-2-yl)-phenol (50 mg, 0.196 mmol) was placed in a microwave tube charged with a stir bar and dissolved 0.5 ml dry dichloromethane, followed by the addition of 2 ml dry ethanol. Tube was sealed with a cap and heated at 160 to 200° C. for one hour in CEM microwave. Solvent was removed under reduced pressure, reconstituted organic in DMSO and purified by Gilson HPLC. The desired compound was concentrated to a white solid as the TFA salt. LC/MS (10-99%) M/Z 267.2, retention time 2.57 minutes.

1. additioncharged with a stir bar
2. customTube was sealed with
3. customa cap
4. customSolvent was removed under reduced pressure
5. custompurified by Gilson HPLC
6. concentrationThe desired compound was concentrated to a white solid as the TFA salt