Sodium Hydroxide → 4-Methoxy-7h-pyrrolo[2,3-d]pyrimidine

HRID 1690004Notes

Reaction equation

HRID 1690004 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.Cl[C:12]1[N:13]=[CH:14][C:15]2[CH:20]=[CH:19][NH:18][C:16]=2[N:17]=1.[OH-:21].[Na+]>CO>[CH3:12][O:21][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:2][O:21][C:12]1[N:13]=[CH:14][C:15]2[CH:20]=[CH:19][NH:18][C:16]=2[N:17]=1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 57067742-Chloro-7H-pyrrolo[2,3-d]pyrimidine

Product 2

HCID 2487924-Methoxy-7h-pyrrolo[2,3-d]pyrimidineHCID 101033172-Methoxy-7H-pyrrolo[2,3-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (3) or 2-methoxy-7H-pyrrolo[2,3-d]pyrimidine (4) is prepared by reacting 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1) or 2-chloro-7H-pyrrolo[2,3-d]pyrimidine (2), respectively, with sodium hydroxide in methanol as described by Girgis, N. et. al., J. Heterocyclic. Chem. 1989, 26:317-325.

Sources & evidence

ORD record
ord-f2ea89aec1a74068873040d99e6a14e7
Source dataset
uspto-grants-2012_04
Patent number
US08153641B2

Reaction notes

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