Potassium Carbonate → HCID 44512046, compound

Participants

Reaction Steps

To propane-1-sulfonic acid {2-fluoro-3-[hydroxy-(7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-amide (P-0005, 79 mg, 0.22 mmol) in 1 mL of tetrahydrofuran, Dess-Martin periodane (101 mg, 0.24 mmol) was added. The reaction was stirred at room temperature for one hour. The reaction was poured into sodium thiosulfate and potassium carbonate solution and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum and purified by silica gel column chromatography eluting with 5% methanol in dichloromethane. Appropriate fractions were combined and concentrated under vacuum to provide the desired compound (P-0006, 75 mg, 95%). MS(ESI) [M+H+]+=363.1.

Provenance & Evidence