2-Fluoro-3-nitrobenzoic acid → 3-Amino-2-fluorobenzoic acid

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Reaction Steps

To 2-fluoro-3-nitro-benzoic acid (28, 2.0 g, 11 mmol) in 45 mL of tetrahydrofuran, 20% palladium hydroxide on carbon (150 mg) was added. The reaction was stirred under hydrogen for 2 hours, then filtered and the filtrate concentrated under vacuum to provide the desired compound 29 as a white solid, which was used in the next step without further purification. MS(ESI) [M−H+]−=154.4.

Provenance & Evidence