Potassium Hydroxide → Propane-1-sulfonic acid{2,4-difluoro-3-[hydroxy-(4-methyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-amide

HRID 1690034Notes

Reaction equation

HRID 1690034 reaction equation
[CH3:1][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[F:11][C:12]1[C:17]([CH:18]=[O:19])=[C:16]([F:20])[CH:15]=[CH:14][C:13]=1[NH:21][S:22]([CH2:25][CH2:26][CH3:27])(=[O:24])=[O:23].[OH-].[K+]>CO>[F:11][C:12]1[C:17]([CH:18]([OH:19])[C:10]2[C:3]3[C:2]([CH3:1])=[N:7][CH:6]=[N:5][C:4]=3[NH:8][CH:9]=2)=[C:16]([F:20])[CH:15]=[CH:14][C:13]=1[NH:21][S:22]([CH2:25][CH2:26][CH3:27])(=[O:24])=[O:23]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 513419594-Methyl-7H-pyrrolo(2,3-d)pyrimidineHCID 53419003N-(2,4-Difluoro-3-formylphenyl)-1-propanesulfonamide

Product 1

HCID 57963260Propane-1-sulfonic acid{2,4-difluoro-3-[hydroxy-(4-methyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-amideYield 37.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 4-methyl-7H-pyrrolo[2,3-d]pyrimidine (42, 0.192 g, 1.44 mmol), propane-1-sulfonic acid (2,4-difluoro-3-formyl-phenyl)-amide (9, 0.456 g, 1.73 mmol), potassium hydroxide (0.263 g, 4.69 mmol) and 1.0 mL of methanol were added to provide a solution. The reaction was allowed to stir at room temperature for 30 hours, then quenched with water and adjusted to pH ˜5 with acetic acid and sodium bicarbonate and extracted with ethyl acetate and saturated sodium chloride. The organic layer was washed with water and brine, dried with magnesium sulfate, filtered and the filtrate concentrated under vacuum. The resulting material was purified by silica gel column chromatography eluting with ethyl acetate and hexane with 4% acetic acid. Appropriate fractions were combined and concentrated under vacuum to provide the desired compound as an off-white solid (P-0055, 215 mg). 1H-NMR(dmso-d6) showed it contains about >80% of the desired compound, used in the next step without further purification. MS(ESI) [M+H−]+=397.1.

Workup

  1. customto provide a solution
  2. customquenched with water
  3. extractionextracted with ethyl acetate and saturated sodium chloride
  4. washThe organic layer was washed with water and brine
  5. dry with materialdried with magnesium sulfate
  6. filtrationfiltered
  7. concentrationthe filtrate concentrated under vacuum
  8. customThe resulting material was purified by silica gel column chromatography
  9. washeluting with ethyl acetate and hexane with 4% acetic acid
  10. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-2d09969b84dc4fde8a32038368aa8d10
Source dataset
uspto-grants-2012_04
Patent number
US08153641B2

Reaction notes

Loading…