4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine → HCID 57963288, compound

HRID 1690041Notes

Reaction equation

HRID 1690041 reaction equation
[CH:1]1([C:4]2[C:5]3[CH:12]=[CH:11][NH:10][C:6]=3[N:7]=[CH:8][N:9]=2)[CH2:3][CH2:2]1.[F:13][C:14]1[C:19]([CH:20]=[O:21])=[C:18]([F:22])[CH:17]=[CH:16][C:15]=1[NH:23][S:24]([C:27]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=1)(=[O:26])=[O:25]>>[CH:1]1([C:4]2[C:5]3[C:12]([CH:20]([OH:21])[C:19]4[C:14]([F:13])=[C:15]([NH:23][S:24]([C:27]5[CH:28]=[CH:29][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:31][CH:32]=5)(=[O:26])=[O:25])[CH:16]=[CH:17][C:18]=4[F:22])=[CH:11][NH:10][C:6]=3[N:7]=[CH:8][N:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 579633004-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidineHCID 58086928HCID 58086928, compound

Product 1

HCID 57963288HCID 57963288, compound

Procedure

4-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine (44) was reacted with N-(2,4-difluoro-3-formyl-phenyl)-4-trifluoromethyl-benzenesulfonamide (10) similarly to the protocol of Example 4, Scheme 2, Step 1.

Sources & evidence

ORD record
ord-b13395f580aa4152a3edbe60631fc3e9
Source dataset
uspto-grants-2012_04
Patent number
US08153641B2

Reaction notes

Loading…