HCID 59608077, compound → HCID 25057271, compound

Participants

Reaction Steps

3.2 117 mg (0.253 mmol) of 1-{2-[3-(2,6-dimethylphenylamino)-6-fluoroimidazo[1,2-a]pyridin-2-yl]benzoyl}-4-methyl-3-thiosemicarbazide and 96 mg (0.300 mmol) of mercury(II) acetate are warmed at 80° C. for 1 hour in 10 ml of methanol in a sealed screw-lid bottle. The mixture is filtered through kieselguhr, rinsed with MeOH, and the filtrate is evaporated to dryness. Purification by silica-gel chromatography (heptane/ethyl acetate) gives 28 mg of (2,6-dimethylphenyl)-{6-fluoro-2-[2-(5-methylamino-1,3,4-oxadiazol-2-yl)phenyl]imidazo[1,2-a]pyridin-3-yl}amine, corresponding to a yield of 26%; MS-FAB (M+H+)=429.8; Rf (HPLC, polar method): 1.58 min.

Provenance & Evidence