HCID 59468967, compound → HCID 59468926, compound

Participants

Reaction Steps

To a solution of phenylmethyl (2R,5R)-2-(aminocarbonyl)-2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-1-pyrrolidinecarboxylate (D74, 85 mg, 0.14 mmol) in methanol (2 ml) was added palladium (10 mg, 10 wt. % dry basis on activated carbon) and the mixture was stirred under hydrogen atmosphere (1 atm) for 30 min. The catalyst was filtered off, the solvent removed under reduced pressure and the crude material purified by chromatography on silica gel using cyclohexane and ethyl acetate (9:1 to 75:25) to afford the title compound (50 mg, 79%) as a colourless oil; Rt (HPLC): 5.00 min; MS: (ES/+) m/z: 459 [MH]+ C25H35FN2O3Si requires 458.

Provenance & Evidence