Sodium Bicarbonate → HCID 59201065, compound

Participants

Reaction Steps

To a solution of 2-(3-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)phenyl) oxirane (550 mg, 1.18 mmol) in tetrahydrofuran (10 mL), boron trifluoride diethyl ether complex (400 μl) and sodium cyanoborohydride (222 mg) were added at 0° C. under an argon atmosphere, and the resultant mixture was stirred. After completion of the reaction, the reaction solution was added with a saturated aqueous solution of sodium hydrogen carbonate, extracted with ethyl acetate, and then concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and the title compound (252 mg, yield 46%) was obtained as a colorless oil.

Provenance & Evidence