5-methyl-5-[4-(propan-2-yloxy)phenyl]imidazolidine-2,4-dione → HCID 59200898, compound

HRID 1690154Notes

Reaction equation

HRID 1690154 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]([C:12]1[CH:27]=[CH:26][C:15]([O:16][C:17]2[CH:18]=[C:19]([CH2:23][CH2:24]O)[CH:20]=[CH:21][CH:22]=2)=[C:14]([CH2:28][CH2:29][CH3:30])[CH:13]=1)([O:8]COC)[C:4]([F:7])([F:6])[F:5].[O:33]1C2C=CC(C3(C)N=CN=C3)=CC=2OC1.C[CH:49]([O:51][C:52]1[CH:57]=[CH:56][C:55]([C:58]2([CH3:65])[NH:62][C:61](=[O:63])[NH:60][C:59]2=[O:64])=[CH:54][CH:53]=1)C>>[O:51]1[C:52]2[CH:57]=[CH:56][C:55]([C:58]3([CH3:65])[NH:62][C:61](=[O:63])[N:60]([CH2:24][CH2:23][C:19]4[CH:20]=[CH:21][CH:22]=[C:17]([O:16][C:15]5[CH:26]=[CH:27][C:12]([C:3]([OH:8])([C:4]([F:5])([F:6])[F:7])[C:2]([F:31])([F:32])[F:1])=[CH:13][C:14]=5[CH2:28][CH2:29][CH3:30])[CH:18]=4)[C:59]3=[O:64])=[CH:54][C:53]=2[O:33][CH2:49]1

Participants

4

Reactant 3

HCID 30521535-methyl-5-[4-(propan-2-yloxy)phenyl]imidazolidine-2,4-dioneHCID 59201065HCID 59201065, compoundHCID 86639405HCID 86639405, compound

Product 1

HCID 59200898HCID 59200898, compound

Procedure

2-(3-(4-(1,1,1,3,3,3-Hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy) phenyl)ethanol was used in place of 1-(3-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propyl phenoxy)phenyl) ethanol; and 5-(benzo[d][1,3]dioxol-5-yl)-5-methylimidazol dine-2,4-dione was used in place of 5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione for a similar operation as Example 27 b), and the title compound was obtained as a colorless oil.

Sources & evidence

ORD record
ord-320456d4e9ef499c93ce7404bffeb2f6
Source dataset
uspto-grants-2012_04
Patent number
US08153634B2

Reaction notes

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