Sodium Thiosulfate → HCID 59200992, compound

Participants

Reaction Steps

To a solution of (4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)pyridin-2-yl)methanol (110 mg, 446 μmol) in dimethylsulfoxide (3 mL), 2-iodoxyperbenzoic acid (136 mg) was added at room temperature, and the resultant mixture was stirred. After completion of the reaction, the reaction solution was added with a saturated aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium hydrogen carbonate at room temperature, extracted with ethyl acetate, and then concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and the title compound (100 mg, yield 92%) was obtained as a colorless oil.

Provenance & Evidence