Water → HCID 59200987, compound

Participants

Reaction Steps

To a solution of 3-bromo-5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy) pyridine (320 mg, 637 μmol) in N,N-dimethylformamide (5 mL), zinc cyanide (112 mg) and tetrakis triphenylphosphine palladium complex (74 mg) were added at room temperature under an argon atmosphere, and the resultant mixture was allowed to react in a microwave (80 watts, 10 minutes). After completion of the reaction, the reaction solution was added with water at room temperature, extracted with ethyl acetate, and then concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and the title compound (239 mg, yield 84%) was obtained as a colorless oil.

Provenance & Evidence