Potassium Carbonate → [5-(Propan-2-yloxy)pyridin-2-yl]methanol

Participants

Reaction Steps

[5-(1-Methylethoxy)pyridin-2-yl]methyl acetate (209 mg) was dissolved in methanol (2.0 mL), added with potassium carbonate (276 mg, 2.0 mmol), and the resultant mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated in vacuo, added with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/ethyl acetate) and [5-(1-methylethoxy)pyridin-2-yl]methanol (137 mg, yield 83%) was obtained as a yellow oil.

Provenance & Evidence