Water → HCID 86639417, compound

Participants

Reaction Steps

To a solution of (2-iodo-5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-dipropylphenoxy) benzaldehyde (25 mg, 0.0404 mmol) in methanol (2.0 mL), sodium borohydride (1.7 mg, 0.445 mmol) was added under ice-cold conditions, and the resultant mixture was stirred for 30 minutes. After completion of the reaction, the reaction solution was added with water under ice-cold conditions and extracted with chloroform. The organic layer was washed with brine and dried over sodium sulfate. (2-Iodo-5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-dipropylphenoxy) phenyl)methanol (27 mg, yield >100%) was obtained as a yellow oil.

Provenance & Evidence