5-methyl-5-[4-(propan-2-yloxy)phenyl]imidazolidine-2,4-dione → HCID 86639424, compound
Reaction equation
[CH2:1](C1C=C(C(OCOC)(C(F)(F)F)C(F)(F)F)C=C(CCC)C=1O)CC.ClC1C=C(B(O)O)C=CN=1.Cl[C:38]1[CH:43]=[C:42]([O:44][C:45]2[C:50]([CH2:51][CH2:52][CH3:53])=[CH:49][C:48]([C:54]([O:63]COC)([C:59]([F:62])([F:61])[F:60])[C:55]([F:58])([F:57])[F:56])=[CH:47][C:46]=2[CH2:67][CH2:68][CH3:69])[CH:41]=[CH:40][N:39]=1.[CH3:70][C:71]1([C:78]2[CH:83]=[CH:82][C:81]([O:84][CH:85]([CH3:87])[CH3:86])=[CH:80][CH:79]=2)[NH:75][C:74](=[O:76])[NH:73][C:72]1=[O:77]>>[F:56][C:55]([F:57])([F:58])[C:54]([C:48]1[CH:47]=[C:46]([CH2:67][CH2:68][CH3:69])[C:45]([O:44][C:42]2[CH:41]=[CH:40][N:39]=[C:38]([CH2:1][N:73]3[C:72](=[O:77])[C:71]([C:78]4[CH:83]=[CH:82][C:81]([O:84][CH:85]([CH3:87])[CH3:86])=[CH:80][CH:79]=4)([CH3:70])[NH:75][C:74]3=[O:76])[CH:43]=2)=[C:50]([CH2:51][CH2:52][CH3:53])[CH:49]=1)([OH:63])[C:59]([F:62])([F:61])[F:60]Participants
5
Procedure
2,6-dipropyl-4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]phenol was used in place of 4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenol, and 2-chloropyridine-4-boronic acid was used in place of 3-(hydroxymethyl)phenylboronic acid in Preparation Example 3 for a similar reaction and treatment, and the obtained 2-chloro-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-dipropylphenoxy) pyridine and 5-methyl-5-(4-(1-methylethoxy)phenyl)imidazolidine-2,4-dione were used for a similar reaction and treatment as Example 40, and the title compound was obtained as a colorless oil.
Workup
- customwas used in place of 3-(hydroxymethyl)phenylboronic acid in Preparation Example 3 for a similar reaction and treatment
Sources & evidence
- ORD record
- ord-a92baad8acd144d38d1c68884325f857
- Source dataset
- uspto-grants-2012_04
- Patent number
- US08153634B2
Reaction notes
Loading…