Hydrochloric Acid → HCID 86639432, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-5-iodoisonicotinate (450 mg, 0.741 mmol) in methanol (3.5 mL), 3N aqueous solution of sodium hydroxide (3.5 mL) was added and the resultant mixture was stirred at room temperature for 1 hour. After completion of the reaction, 5% aqueous solution of hydrochloric acid and a saturated aqueous solution of sodium hydrogen carbonate were added, extracted with chloroform/methanol, and the organic layer was dried using sodium sulfate. After filtration, the filtrate was concentrated in vacuo, and 2-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-5-iodoisonicotinic acid (441 mg, yield >100%) was obtained as a yellow oil.

Provenance & Evidence