HCID 86639434, compound → HCID 86639433, compound

Participants

Reaction Steps

To a solution of 5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)-2-(2-hydroxyethyl)pyridine 1-oxide (2.29 g, 4.74 mmol) in acetic acid (24 mL), zinc powder (6.2 g, 94.7 mmol) was added, and the resultant mixture was stirred at room temperature for 4 hours. After completion of the reaction, the reaction solution was filtered using celite, added with a saturated aqueous solution of sodium hydrogen carbonate, and extracted with ethyl acetate. The organic layer was washed with brine and dried using sodium sulfate. After filtration, the filtrate was concentrated in vacuo. The obtained residue was purified using silica-gel column chromatography (hexane/acetone) and 2-(5-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenoxy)pyridin-2-yl)ethanol (2.0 g, yield 90%) was obtained as a yellow oil.

Provenance & Evidence