Acetic Acid → HCID 44198503, compound

Participants

Reaction Steps

To (R)-2-amino-N-(isoquinolin-6-yl)-2-phenylacetamide dihydrochloride (E2) in MeOH was added CH2O (37%), AcOH and NaCNBH3. After stirring for 1.5 hours the solution was poured into NaHCO3(sat) and extracted with EtOAc, dried (Na2SO4), filtered and concentrated. Column chromatography Hexanes/EtOAc gave pure (R)-2-(dimethylamino)-N-(isoquinolin-6-yl)-2-phenylacetamide. To (R)-2-(dimethyl amino)-N-(isoquinolin-6-yl)-2-phenylacetamide was added CH2Cl2 and HCl (4N in dioxane) and the solvents were evaporated to give pure (R)-2-(dimethylamino)-N-(isoquinolin-6-yl)-2-phenylacetamide dihydrochloride (E3).

Provenance & Evidence