HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyanuric fluoride | HCID 12664 | — |
| Reactant | (R)-2-((tert-Butoxycarbonyl)amino)-2-(thiophen-3-yl)acetic acid | HCID 7023006 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate | HCID 57788121 | — |
Reaction Conditions
| Temperature | -10 °C |
|---|
Reaction Steps
To (R)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid in CH2Cl2 cooled to −10° C. was added pyridine and cyanuric fluoride. The solution was stirred for 1 hour at −10° C., quenched with ice and extracted with CH2Cl2 and ice cold water, dried (Na2SO4), filtered and evaporated to give (R)-tert-butyl 2-fluoro-2 oxo-1-(thiophen-3-yl)ethylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153654B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f9bdb0b1240d4803b0677c6b0609647e |
| Source note | uspto-grants-2012_04 |