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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690254Generated: November 1, 2026

Methanol → Methyl 3-thienylacetate

https://huagongshe.com/reaction/1690254

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
Reactant3-Thiophenacetic acidHCID 23404—
ProductMethyl 3-thienylacetateHCID 94041—

Reaction Steps

To 2-(thiophen-3-yl)acetic acid in MeOH at 0° C. was added TMS-CH2N2. The solution was stirred for 3 hours then quenched with a few drops of AcOH. The solvents were evaporated. Column chromatography (SiO2, 3-15% EtOAc/Hex) gave pure methyl 2-(thiophen-3-yl)acetate (E41).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153656B2
Source datasetuspto-grants-2012_04
ORD IDord-ece1f5a62cc24514bcbe8ae5796bac21
Source noteuspto-grants-2012_04