Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 59161758 | HCID 59161758 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 59161750 | HCID 59161750 | — |
Reaction Steps
To 3-(tert-butoxycarbonylamino)-3-(thiophen-3-yl)propyl 4-methylbenzenesulfonate (E73B) in DMSO is added NaCN, and the solution is heated to 90° C. for 2 hours. The reaction is cooled, poured into NaCl (sat), and extracted with EtOAc. The organics are dried (Na2SO4), filtered, and evaporated. Column chromatography (SiO2, 25% EtOAc/Hexanes) gives pure tert-butyl 2-cyano-1-(thiophen-3-yl)ethylcarbamate (E73C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08153656B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-79494ecd2cc5435fbc5bad2c054bde9a |
|---|
| Source note | uspto-grants-2012_04 |
|---|
