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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690340Generated: October 26, 2026

Ethyl indole-2-carboxylate → 1-ethyl-5-fluoro-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/1690340

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant5-fluoro-1H-indole-3-carbaldehydeHCID 259089—
Product1-ethyl-5-fluoro-1H-indole-3-carbaldehydeHCID 2213899857%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 5-fluoro-1H-indole-3-carboxaldehyde (0.41 g, 2.5 mmole) for the ethylindole-2-carboxylate, the title compound (0.20 g, 57%) was prepared as a viscous oil: MS (ES) m/e 191 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153652B2
Source datasetuspto-grants-2012_04
ORD IDord-46671a4333db4234b86ddedcae5554b0
Source noteuspto-grants-2012_04