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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1690374Generated: November 1, 2026

Ethyl indole-2-carboxylate → Methyl N-methylindole-6-carboxylate

https://huagongshe.com/reaction/1690374

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
ReactantMethyl indole-6-carboxylateHCID 639844—
ProductMethyl N-methylindole-6-carboxylateHCID 63984395%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting methyl indole-6-carboxylate for the ethyl indole-2-carboxylate, the title compound (2.5 g, 95%) was obtained as white solid: MS (ES) m/e 190.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08153652B2
Source datasetuspto-grants-2012_04
ORD IDord-4dfaa4423836448f80a0baecbe226972
Source noteuspto-grants-2012_04