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N-Methyl-N-[(2-methyl-1H-indol-3-yl)methyl]amine → HCID 178482984、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methyl-N-[(2-methyl-1H-indol-3-yl)methyl]amine | HCID 10954023 | — |
| 反応物 | 1-Methyl-3-(methylaminomethyl)indole | HCID 10986778 | — |
| 反応物 | (e)-3-(2-Oxo-2,3-dihydro-1h-indol-5-yl)acrylic acid hydrochloride salt | HCID 66905016 | — |
| 反応物 | HCID 178525338 | HCID 178525338 | — |
| 生成物 | HCID 178482984 | HCID 178482984 | 90% |
反応手順
According to the procedure of Example 4, except substituting (E)-3-(3H-imidazo[4,5-b]pyridin-6-yl)acrylate (0.14 g, 0.74 mmole), from Preparation 6, for the (E)-3-(2-oxo-2,3-dihydro-1H-indol-5-yl)acrylic acid hydrochloride salt, and substituting 1-methyl-3-(methylaminomethyl)indole (0.14 g, 0.81 mmole) for the 2-methyl-3-(methylaminomethyl)-1H-indole, the title compound (0.23 g, 89%) was prepared as a light yellow solid: MS (ES) m/e 346 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08153652B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-afbed305f80541478b29785cd48508c7 |
| 出典メモ | uspto-grants-2012_04 |