HRID1690410

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)CNc1ccc(/C=C/C(=O)N(C)Cc2c(C)[nH]c3ccccc23)cn1

HCID10363109

未命名化合物

结构：COC(=O)CNc1ccc(/C=C/C(=O)N(C)Cc2cn(C)c3c(Cl)cccc23)cn1

HCID11743240

未命名化合物

PRODUCTS

生成物

结构：CN(Cc1cn(C)c2c(Cl)cccc12)C(=O)/C=C/c1ccc(NCC(=O)O)nc1

HCID10001757

未命名化合物

收率 100.4%

PROCEDURE

实验过程

According to the procedure of Example 20, except substituting (E)-N-(7-chloro-1-methyl-1H-indol-3-ylmethyl)-3-[6-[N-(methoxycarbonylmethyl)amino]pyridin-3-yl]-N-methylacrylamide (0.75 g, 1.8 mmole) for the (E)-3-[6-[N-(methoxycarbonylmethyl)amino]pyridin-3-yl]-N-methyl-N-(2-methyl-1H-indol-3-ylmethyl)acrylamide, the title compound (0.746 g, 100%) was prepared as a white solid: MS (ES) m/e 413.2 (M+H)+.