3-(dimethoxymethyl)aniline → HCID 66907282, compound

HRID 1690481Notes

Reaction equation

HRID 1690481 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([OH:18])=O)=[C:11]([O:19][CH3:20])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][O:22][CH:23]([C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29])[O:24][CH3:25]>>[CH3:21][O:22][CH:23]([C:26]1[CH:27]=[C:28]([NH:29][C:16](=[O:18])[CH2:15][C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]=2[O:19][CH3:20])[CH:30]=[CH:31][CH:32]=1)[O:24][CH3:25]

Participants

3

Reactant 2

HCID 2325713-(dimethoxymethyl)anilineHCID 110655714-Benzyloxy-2-methoxyphenylacetic acid

Product 1

HCID 66907282HCID 66907282, compoundYield 51%

Procedure

Using an analogous procedure to that described in Example 1, 2-(4-benzyloxy-2-methoxyphenyl)acetic acid was reacted with 3-(1,1-dimethoxymethyl)aniline to give N-[3-(1,1-dimethoxymethyl)phenyl]-2-(4-benzyloxy-2-methoxyphenyl)acetamide in 51% yield. The compound was obtained as a mixture of the dimethoxyacetal and the corresponding aldehyde.

Sources & evidence

ORD record
ord-0073022a169e47c6935c4f2691b82a16
Source dataset
uspto-grants-2012_04
Patent number
US08153643B2

Reaction notes

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