HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-hydroxybenzeneacetic acid → HCID 66907480, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-hydroxybenzeneacetic acid | HCID 68014 | — |
| Reactant | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | HCID 11289942 | — |
| Product | HCID 66907480 | HCID 66907480 | 41% |
Reaction Steps
Using an analogous procedure to that described in the portion of Note [1] below Table III in Example 8 that is concerned with the preparation of starting materials, 4-chloro-6,7-di-(2-methoxyethoxy) quinazoline was reacted with 2-(3-fluoro-4-hydroxyphenyl)acetic acid to give 2-{3-fluoro-4-[6,7-di-(2-methoxyethoxy)quinazolin-4-yloxy]phenyl}acetic acid in 41% yield; Mass Spectrum: M+H+ 447.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153643B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f6036d03762547e8a98a126b44b83243 |
| Source note | uspto-grants-2012_04 |