Acetonitrile → Pentanenitrile, 4,4-dimethyl-3-oxo-

HRID 1690487Notes

Reaction equation

[C:1]([O:7]CC)(=O)[C:2]([CH3:5])([CH3:4])[CH3:3].[C:10](#[N:12])[CH3:11]>>[CH3:5][C:2]([CH3:3])([CH3:4])[C:1](=[O:7])[CH2:11][C:10]#[N:12]

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 19838Ethyl pivalate

Product 1

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

Procedure

Using analogous procedures to those described in the portion of Note [36] immediately above that is concerned with the preparation of starting materials, ethyl pivaloate was reacted with acetonitrile to give 4,4-dimethyl-3-oxopentanenitrile which in turn was reacted with hydrazine hydrate to give the required starting material.

Sources & evidence

ORD record: ord-f0660bd865c54a379601523202ffb243
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153643B2

Reaction notes

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