3-Fluoro-4-hydroxybenzeneacetic acid → HCID 66906714, compound

Participants

Reaction Steps

Using an analogous procedure to that described in the portion of Note [1] below Example 8 that is concerned with the preparation of starting materials, 4-chloro-6-methoxy-7-(2-tetrahydropyran-2-yloxyethoxy) quinazoline was reacted with 2-(3-fluoro-4-hydroxyphenyl) acetic acid to give 2-{3-fluoro-4-[6-methoxy-7-(2-tetrahydropyran-2-yloxyethoxy) quinazolin-4-yloxy]phenyl}acetic acid in 52% yield; Mass Spectrum: M+H+ 473.

Provenance & Evidence