HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[4-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl]acetic acid → N-[5-(N-tert-butoxycarbonyl-N-propylamino) pyridin-2-yl]-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[4-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl]acetic acid | HCID 66906632 | — |
| Reactant | 2-amino-5-(N-tert-butoxycarbonyl-N-propylamino)pyridine | HCID 66907348 | — |
| Product | N-[5-(N-tert-butoxycarbonyl-N-propylamino) pyridin-2-yl]-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetamide | HCID 66907130 | — |
Reaction Steps
Using a similar procedure to that described in Example 6, 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetic acid was reacted with 2-amino-5-(N-tert-butoxycarbonyl-N-propylamino)pyridine to give N-[5-(N-tert-butoxycarbonyl-N-propylamino) pyridin-2-yl]-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]acetamide; Mass Spectrum: M+H+ 574.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153643B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-af694e90d29c4a8aba2bebdec1bccaef |
| Source note | uspto-grants-2012_04 |