4-Chloro-7-ethoxy-6-methoxyquinazoline → HCID 66907900, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 15, N-(5-dimethylaminopyridin-2-yl)-2-(4-hydroxy-2-methoxyphenyl)acetamide was reacted with 4-chloro-7-ethoxy-6-methoxyquinazoline. There was thus obtained the title compound in 67% yield; 1H NMR: (CDCl3) 1.59 (t, 3H), 2.92 (s, 6H), 3.75 (s, 2H), 3.91 (s, 3H), 4.07 (s, 3H), 4.29 (d, 1H), 4.32 (d, 1H), 6.85 (s, 1H), 6.87 (m, 1H), 7.11 (m, 1H), 7.32 (s, 1H), 7.4 (d, 1H), 7.54 (s, 1H), 7.72 (d, 1H), 8.09 (d, 1H), 8.20 (br s, 1H), 8.63 (s, 1H); Mass Spectrum: M+H+ 504.

Provenance & Evidence