4-Chloro-6,7-dimethoxyquinazoline → HCID 66906492, compound

Participants

Reaction Steps

Using an analogous procedure to that described in the portion of Note [1] below Example 8 that is concerned with the preparation of starting materials, 4-chloro-6,7-dimethoxyquinazoline was reacted with 2-(4-hydroxy-2-methoxyphenyl)acetic acid to give 2-[4-(6,7-dimethoxyquinazolin-4-yloxy)-2-methoxyphenyl]acetic acid in 87% yield; 1H NMR: (DMSOd6) 3.55 (s, 2H), 3.75 (s, 3H), 3.98 (s, 3H), 3.99 (s, 3H), 6.83 (d, 1H), 6.97 (s, 1H), 7.27 (d, 1H), 7.39 (s, 1H), 7.55 (s, 1H), 8.57 (s, 1H); Mass Spectrum: M+H+ 371.

Provenance & Evidence