Trifluoroacetic acid → HCID 86634411, compound

Participants

Reaction Steps

Using an analogous procedure to that described in the second paragraph of Example 21, (2S)-2-(N-tert-butoxycarbonylamino)-2-[4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N-(4,5-dimethylthiazol-2-yl)acetamide was reacted with trifluoroacetic acid to give the title compound in 34% yield; 1H NMR: (DMSOd6) 2.13 (s, 3H), 2.21 (s, 3H), 3.97 (s, 3H), 3.98 (s, 3H), 4.64 (s, 1H), 7.25 (d, 2H), 7.38 (s, 1H), 7.54 (m, 3H), 8.53 (s, 1H); Mass Spectrum: M+H+466.

Provenance & Evidence